您好,欢迎来到试剂信息网! [登录] [免费注册]
试剂信息网
位置:首页 > 产品库 > 7-oxo Staurosporine
立即咨询
咨询类型:
     
*姓名:
*电话:
*单位:
Email:
*留言内容:
请详细说明您的需求。
*验证码:
 
7-oxo Staurosporine
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
7-oxo Staurosporine图片
CAS NO:125035-83-8
规格:98%
分子量:480.5
包装与价格:
包装价格(元)
1mg电议
5mg电议

产品介绍
7-oxo Staurosporine is an antibiotic originally isolated from S.
CAS:125035-83-8
分子式:C28H24N4O4
分子量:480.5
纯度:98%
存储:Store at -20°C

Background:

7-oxo Staurosporine is an antibiotic originally isolated from S. platensis with diverse biological activites. It inhibits PKC, PKA, phosphorylase kinase, EGFR, and c-Src in vitro (IC50s = 9, 26, 5, 200, and 800 nM, respectively). 7-oxo Staurosporine induces cell cycle arrest in the G2/M phase in human leukemia K562 cells with a minimal effective dose (MED) of 30 ng/ml. It is cytotoxic to P388 mouse leukemia cells that are resistant and susceptible to doxorubicin . 7-oxo Staurosporine inhibits growth of the mycelial, but not yeast form of C. albicans, C. krusei, C. tropicalis, and C. lusitaniae (MICs = 3.1-25 μg/ml). It increases sphingomyelin synthesis in CHO-K1 cells when used at a concentration of 50 nM.