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Cerdulatinib
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Cerdulatinib图片
CAS NO:1369761-01-2
包装与价格:
包装价格(元)
10mg电议
25mg电议
50mg电议
10mM * 1mL in DMSO电议

产品名称
PRT062070, PRT2070, PRT-2070
产品介绍

生物活性

Cerdulatinib (PRT-062070)是多靶点酪氨酸激酶抑制剂,对JAK1/JAK2/JAK3/TYK2和Syk的IC50分别为12 nM/6 nM/8 nM/0.5 nM和32 nM。

Targets

TargetValue
TYK2IC50: 0.5nM
MST1IC50: 4nM
ARK5IC50: 4nM
MLK1IC50: 5nM
FmsIC50: 5nM
AMPKIC50: 6nM
JAK2IC50: 6nM
JAK3IC50: 8nM
TBK1IC50: 10nM
MARK1IC50: 10nM
JAK1IC50: 12nM
PAR1B-aIC50: 13nM
TSSKIC50: 14nM
MST2IC50: 15nM
GCKIC50: 18nM
JNK3IC50: 18nM
RSK2IC50: 20nM
RSK4IC50: 28nM
SykIC50: 32nM
Chk1IC50: 42nM
FLT4IC50: 51nM
FLT3IC50: 90nM
RETIC50: 105nM
ITKIC50: 194nM

化学数据

目录号A14210
作用机制Inhibitor (抑制剂)
M. Wt482
FormulaC20H28ClN7O3S
Purity>99%
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for36 months.
In solution, store at -20ºC and use within3 monthsto prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

CAS No.1369761-01-2
SynonymsPRT062070, PRT2070, PRT-2070
SMILESCCS(=O)(=O)N1CCN(CC1)C2=CC=C(C=C2)NC3=NC=C(C(=N3)NC4CC4)C(=O)N.Cl

溶解度

In vitro (25°C)DMSOWarmed: 42 mg/mL (87.14 mM)
WaterInsoluble
EthanolInsoluble
In vivo5% DMSO+corn oil2 mg/mL
*<1 mg/ml means slightly soluble or insoluble.
*Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

储备液配制

Concentration / Solvent Volume / Mass1 mg5 mg10 mg
0.1 mM20.75 mL103.73 mL207.47 mL
0.5 mM4.15 mL20.75 mL41.49 mL
1 mM2.07 mL10.37 mL20.75 mL
5 mM0.41 mL2.07 mL4.15 mL

*The above data is based on the productmolecular weight 482. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.