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OSMI-1
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
OSMI-1图片
CAS NO:1681056-61-0
规格:98%
分子量:563.64
包装与价格:
包装价格(元)
1mg电议
5mg电议
10mg电议
25mg电议

产品介绍
OSMI-1 is a cell permeable inhibitor of OGT (O-GlcNAc transferase)
CAS:1681056-61-0
分子式:C28H25N3O6S2
分子量:563.64
纯度:98%
存储:Store at -20°C

Background:

OSMI-1 is a quinolinone-6-sulfonamide that inhibits O-GlcNAc transferase (OGT; IC50 = 2.7 μM) in vitro.[1] It is cell permeable and inhibits global O-GlcNAcylation in a dose-dependent manner in CHO cells. OSMI-1 induces a mass shift of nucleoporin62 (Nup62) that corresponds to the loss of O-GlcNAc residues and decreases levels of cellular O-GlcNAcase (OGA). OSMI-1 (50 μM) also causes a 50% decrease in CHO cell viability after 24 hours.
Reference:
[1]. Ortiz-Meoz, R.F., Jiang, J., Lazarus, M.B., et al. A small molecule that inhibits OGT activity in cells. ACS Chem Biol. 10(6), 1392-1397 (2015).