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Indomethacin heptyl ester
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Indomethacin heptyl ester图片
CAS NO:282728-47-6
规格:98%
分子量:456
包装与价格:
包装价格(元)
1mg电议
5mg电议
10mg电议
50mg电议

产品介绍
non-selective inhibitor of both COX-1 and COX-2
CAS:282728-47-6
分子式:C26H30ClNO4
分子量:456
纯度:98%
存储:Store at -20°C

Background:

Indomethacin heptyl ester is a potent and selective COX-2 inhibitor with IC50 value of 0.04 μM [1].


The key step in thromboxane and prostaglandin biosynthesis involves the conversion of arachidonic acid to prostaglandin H2 (PGH2), a reaction catalyzed by the cyclooxygenase (COX) and peroxidase activities of prostaglandin endoperoxide synthase or cyclooxygenase. COX is composed of COX-1 and COX-2. COX-2 plays important role in prostaglandin biosynthesis in inflammatory cells and in the central nervous system [1].


Indomethacin is a potent COX-1 and COX-2 inhibitor with IC50 value of 0.05 μM and 0.75 μM, and is also a nonsteroidal antiinflammatory drug. Indomethacin is a substituted indole acetic acid and many of the structurally diverse indomethacin esters and amides show enhanced selectivity for the COX-2 isoform. Indomethacin heptyl ester was more potent and selective COX-2 inhibitor with IC50 value of 0.04 μM and >66 μM for human recombinant COX-2 and COX-1, respectively [1].


Reference:
[1].  Kalgutkar AS, Marnett AB, Crews BC, et al. Ester and amide derivatives of the nonsteroidal antiinflammatory drug, indomethacin, as selective cyclooxygenase-2 inhibitors. J Med Chem. 2000 Jul 27;43(15):2860-70.