HLE inhibitor
CAS:344930-95-6
分子式:C27H32N4O7S
分子量:556.63
纯度:98%
存储:Store at -20°C
Background:
High affinity, potent inhibitor of human leukocyte elastase (HLE) (IC
50= 3.9 nM). Displays species-selectivity (K
ivalues are 0.017, 1.70, 3.01, 58 and > 100 nM?for human, mouse, rat, rabbit and porcine elastase respectively). Inhibits HLE-induced lung hemorrhage in mice (ID
50= 2.8 mg/kg) and reduces infarct size in an
in vivoacute model of coronary ischemia-reperfusion injury. Orally active.