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Ursolic acid
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Ursolic acid图片
CAS NO:77-52-1
包装:20mg
规格:98%
市场价:765元
分子量:456.68

产品介绍
Triterpenoid with anti-tumor properties
CAS:77-52-1
分子式:C30H48O3
分子量:456.68
纯度:98%
存储:Store at -20°C

Background:

IC50: 2.5 μg/mL for P3HR1 cells; 17.79 μg/mL for myelogenous leukemia K562 cells


Ursolic acid, an ursane-type pentacyclic triterpenic acid, belongs to the cyclosqualenoid family, has been reported to be useful in cancer prevention and treatment. Several inflammatory signaling cascades including nuclear factor-kB and cyclooxygenase-2 have been linked with different stages of cancer progression.


In vitro: Ursolic acid was reported to suppress the proliferation of a number of tumor cells, induce apoptosis and inhibit metastasis, tumor promotion, and angiogenesis. Ursolic acid could inhibit NF-kB activation induced by carcinogenic agents through the suppression of IkBa kinase and p65/RelA phosphorylation [1].


In vivo: In vivo, ursolic acid has been reported to inhibit tumor growth in various cancer animal models. In nude mice, ursolic acid treatment for 6 weeks inhibited the growth of DU145 cells without any significant effect on body weight. In addition, ursolic acid treatment produced chemopreventive effects in the transgenic adenocarcinoma of mouse prostate mouse model [1].


Clinical trial: Sixty-three subjects received a single dose of ursolic acid liposomes. The clinical results showed that liposomal ursolic acid had manageable toxicities with MTD of 98 mg/m2. The DLT were primarily diarrhea and hepatotoxicity. Additionally, ursolic acid liposomeal formulation had a linear pharmacokinetic profile [1].


Reference:
[1] Shanmugam MK,Dai X,Kumar AP,Tan BK,Sethi G,Bishayee A.  Ursolic acid in cancer prevention and treatment: molecular targets, pharmacokinetics and clinical studies. Biochem Pharmacol.2013 Jun 1;85(11):1579-87.