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BIBF 1202
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
BIBF 1202图片
CAS NO:894783-71-2
规格:98%
分子量:525.6
包装与价格:
包装价格(元)
10mg电议
50mg电议
1mg电议
5mg电议

产品介绍
BIBF 1202是BIBF 1120的羧酸盐代谢物,抑制 VEGFR2 激酶的 IC50 值为62 nM。
CAS:894783-71-2
分子式:C30H31N5O4
分子量:525.6
纯度:98%
存储:Store at -20°C

Background:

BIBF 1202 is the carboxylate metabolite of BIBF 1120 which inhibits VEGFR2 kinase with an IC50 of 62 nM. IC50: 62 nM (VEGFR2)[1]


The major metabolic pathway for BIBF 1120 is methyl ester cleavage to BIBF 1202. Subsequently, the free carboxyl group of BIBF 1202 is glucuronidated to 1-O-acylglucuronide[2].



[1]. Hilberg F, et al. BIBF 1120: triple angiokinase inhibitor with sustained receptor blockade and good antitumorefficacy. Cancer Res. 2008 Jun 15;68(12):4774-82. [2]. Stopfer P, et al. Pharmacokinetics and metabolism of BIBF 1120 after oral dosing to healthy male volunteers. Xenobiotica. 2011 Apr;41(4):297-311.