Carbazeran is an inhibitor of phosphodiesterase 2 (PDE2) and PDE3.
CAS：70724-25-3
分子式：C18H24N4O4
分子量：360.4
纯度：98%
存储：Store at -20°C

Background:

Carbazeran is an inhibitor of phosphodiesterase 2 (PDE2) and PDE3. It inhibits cAMP hydrolysis (IC50 = 4.1 µM in rabbit heart ventricles) selectively over cGMP hydrolysis (IC50 = 171 µM). It induces positive inotropic (EC50 = 100 µM) and negative chronotropic effects in isolated rabbit papillary muscle and right atria, respectively. Carbazeran is also a substrate for the enzyme aldehyde oxidase (AOX1), which is involved in the metabolism of xenobiotics.