| CAS NO: | 288250-47-5 |
| 规格: | ≥98% |
| 包装 | 价格(元) |
| 1mg | 电议 |
| 2mg | 电议 |
| 5mg | 电议 |
| 10mg | 电议 |
| 25mg | 电议 |
| 50mg | 电议 |
| 100mg | 电议 |
| 250mg | 电议 |
| 500mg | 电议 |
| Molecular Weight (MW) | 505.01 |
|---|---|
| Formula | C27H29ClN6O2 |
| CAS No. | 288250-47-5 |
| Storage | -20℃ for 3 years in powder form |
| -80℃ for 2 years in solvent | |
| Solubility (In vitro) | DMSO: 11 mg/mL (21.8 mM) |
| Water: <1 mg/mL | |
| Ethanol: <1 mg/mL | |
| Other info | Chemical Name: 1-(4-chlorophenyl)-N-(3-cyano-4-(4-morpholinopiperidin-1-yl)phenyl)-5-methyl-1H-pyrazole-4-carboxamide InChi Key: BWZNJVZTAWBIFG-UHFFFAOYSA-N InChi Code: InChI=1S/C27H29ClN6O2/c1-19-25(18-30-34(19)24-5-2-21(28)3-6-24)27(35)31-22-4-7-26(20(16-22)17-29)33-10-8-23(9-11-33)32-12-14-36-15-13-32/h2-7,16,18,23H,8-15H2,1H3,(H,31,35) SMILES Code: O=C(C1=C(C)N(C2=CC=C(Cl)C=C2)N=C1)NC3=CC=C(N4CCC(N5CCOCC5)CC4)C(C#N)=C3 |
| Synonyms | Y-320; Y320; Y 320 |
| In Vitro | In vitro activity: Y-320 also inhibits the production of IFN-γ and TNF-α by mouse CD4 T cells stimulated with IL-15, CXCL12, and anti-CD3 mAb. Cell Assay: Y-320 inhibited IL-17 production by CD4 T cells induced by IL-15 with IC50 values of 20-60 NM. |
|---|---|
| In Vivo | Y-320 (0.3-3 mg/kg p.o.) ameliorates collagen-induced arthritis (CIA) in Mice with a reduction of IL-17 mRNA in arthritic joints, and also shows therapeutic effects on CIA in cynomolgus monkeys. Moreover, Y-320 shows a synergistic effect in combination with anti-TNF-α mAb on chronic-progressing CIA in mice. |
| Animal model | DBA/1J mice with type II collagen-induced arthritis (CIA) |
| Formulation & Dosage | Suspended in a 0.5% hydroxypropylmethylcellulose (HPMC); 3 mg/kg; p.o. |
| References | Pharmaceuticals (Basel). 2013 Dec 23;7(1):1-17. |
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