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Dutogliptin
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Dutogliptin图片
CAS NO:852329-66-9
规格:98%
分子量:241.1
包装与价格:
包装价格(元)
1mg电议
5mg电议
10mg电议
20mg电议

产品介绍
Dutogliptin是一种口服有效的选择性二肽基肽酶-4(DPP4)抑制剂。
CAS:852329-66-9
分子式:C10H20BN3O3
分子量:241.1
纯度:98%
存储:Store at -20°C

Background:

Dutogliptin is an orally available, potent, and selective dipeptidyl peptidase-4 (DPP4) inhibitor.



Dutogliptin is highly water soluble (>2000 mg/mL), has low cellular permeability, exhibits low plasma protein binding (11%) and is rapidly absorbed with a Tmax of 3-4 h and a half-life of 10-13 h. The compound is metabolically stable and does not inhibit or induce the activity of major CYP450s[2].


[1]. Marier JF, et al. Population pharmacokinetic analysis of dutogliptin, a selective dipeptidyl peptidase-4 inhibitor. Clin Pharmacol Drug Dev. 2014 Jul;3(4):297-304. [2]. Pattzi HM, et al. Dutogliptin, a selective DPP4 inhibitor, improves glycaemic control in patients with type 2 diabetes: a 12-week, double-blind, randomized, placebo-controlled, multicentre trial. Diabetes Obes Metab. 2010 Apr;12(4):348-55.