| CAS NO: | 1164470-53-4 |
| 规格: | ≥98% |
| 包装 | 价格(元) |
| 2mg | 电议 |
| 5mg | 电议 |
| 10mg | 电议 |
| 25mg | 电议 |
| 50mg | 电议 |
| 100mg | 电议 |
| 250mg | 电议 |
| 500mg | 电议 |
| Molecular Weight (MW) | 463.21 |
|---|---|
| Formula | C18H15Cl4N3OS |
| CAS No. | 1164470-53-4 |
| Storage | -20℃ for 3 years in powder form |
| -80℃ for 2 years in solvent | |
| Solubility (In vitro) | DMSO: 93 mg/mL (200.78mM) |
| Water: <1 mg/mL | |
| Ethanol: <1 mg/mL | |
| Other info | Chemical Name: 3--Phenyl-N-(2,2,2-trichloro-1-((((4-chlorophenyl)amino)carbonothioyl)amino)ethyl)acrylamide InChi Key: TVNBASWNLOIQML-IZZDOVSWSA-N InChi Code: InChI=1S/C18H15Cl4N3OS/c19-13-7-9-14(10-8-13)23-17(27)25-16(18(20,21)22)24-15(26)11-6-12-4-2-1-3-5-12/h1-11,16H,(H,24,26)(H2,23,25,27)/b11-6+ SMILES Code: O=C(NC(NC(NC1=CC=C(Cl)C=C1)=S)C(Cl)(Cl)Cl)/C=C/C2=CC=CC=C2 |
| Synonyms | SAL-003; SAL 003; SAL003 |
| In Vitro | In vitro activity: Sal003 increases eIF2α phosphorylation status by blocking eIF2a phosphatases in cells. In mouse embryonic fibroblasts (MEFs), Sal003 causes dissociation of polysomes by increasing eIF2a phosphorylation. Sal003 impairs late-long-term potentiation (L-LTP) in an ATF4-dependent mode in hippocampal slices from WT mice. In addition, eIF2α phosphorylation by Sal003 also enhances apoptotic signaling induced by subtilase cytotoxin (SubAB). Cell Assay: Sal003 specifically prevents dephosphorylation of eIF2α by blocking eIF2α phosphatases. In Sal003-treated cells polysomes dissociated and consistent with this β-actin mRNA shifted to lighter fractions, reflecting the inhibition of general translation |
|---|---|
| In Vivo | Sal003 impairs spatial long-term memory formation in rats. |
| Animal model | Rats |
| Formulation & Dosage | Dissolved in DMSO and further diluted in 0.9% NaCl to a final DMSO concentration of 0.1%; 2 μL of 20 μM; Intrahippocampal Injection. |
| References | Mol Biol Cell. 2006 Nov;17(11):4632-44; Cell. 2007 Apr 6;129(1):195-206. |
m.cnreagent.com