N-(n-Butyl)deoxygalactonojirimycin is an inhibitor of α-D-galactosidase.
CAS：141206-42-0
分子式：C10H21NO4
分子量：219.3
纯度：98%
存储：Store at -20°C

Background:

N-(n-Butyl)deoxygalactonojirimycin is an inhibitor of α-D-galactosidase. It has also been shown to prevent glucosylceramide biosynthesis both in vitro and in mouse models of lysosome storage disorders by inhibiting the ceramide-specific glucosyltransferase, UDP-glucose ceramide glucosyltransferase (IC50 = 41.4 µM) without affecting α-glucosidase I and II or β-glucocerebrosidase (IC50s >1 mM). This compound has been used to sensitize cultured chronic lymphocytic leukemia cells to the chemotherapeutic agents cladribine , chlorambucil , and fludarabine .