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Fusicoccin
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Fusicoccin图片
CAS NO:20108-30-9
规格:98%
分子量:680.8
包装与价格:
包装价格(元)
500ug电议
1mg电议

产品介绍
Fusicoccin is a phytotoxin originally isolated from F.
CAS:20108-30-9
分子式:C36H56O12
分子量:680.8
纯度:98%
存储:Store at -20°C

Background:

Fusicoccin is a phytotoxin originally isolated from F. amygdali that induces death of tomato plants when used at concentrations ranging from 0.1 to 0.2 μg/ml. Topical administration of fusicoccin to tobacco (N. tabacum), sorghum (S. bicolor), cucumber (C. sativa), lucerne (M. sativa), and pokeweed (P. Americana) induces permanent opening of leaf stomata and wilting. Fusicoccin binds to the preformed complex between plasma membrane H+-ATPase and a 14-3-3 protein in plants to stabilize and activate the enzyme leading to dysregulated solute transport and control of transmembrane electric potential. It also stabilizes eukaryotic 14-3-3 protein interactions with binding partners containing a C-terminal 14-3-3 recognition motif, also known as a mode 3 motif, such as ERα, GPIbα, TASK3, CTFR, and p53 in vitro. Fusicoccin stimulates cortical neurite outgrowth in a 14-3-3 protein-dependent manner (EC50 = 29 μM). In vivo, topical administration of fusicoccin to the injury site reduces collapse and retraction of severed axons in a mouse model of spinal cord injury.