K+ channel blocker and acetylcholine release stimulator
CAS：160588-45-4
分子式：C26H18F2N2O
分子量：412.44
纯度：98%
存储：Store at -20°C

Background:

DMP-543 (XR-543) is a KV7 channel blocker, also acts as a potent neurotransmitter release enhancer[1][2].

DMP-543 enhances [3H]ACh release from rat brain slices, with an EC50 of 700 nM[2].

参考文献:
[1]. Ipavec V, et al. KV7 channels regulate muscle tone and nonadrenergic noncholinergic relaxation of the rat gastric fundus. Pharmacol Res. 2011 Oct;64(4):397-409.
[2]. Zaczek R, et al. Two new potent neurotransmitter release enhancers, 10,10-bis(4-pyridinylmethyl)-9(10H)-anthracenone and 10,10-bis(2-fluoro-4-pyridinylmethyl)-9(10H)-anthracenone: comparison to linopirdine. J Pharmacol Exp Ther. 1998 May;285(2):724-30.