3-Mercaptopicolinic acid is an inhibitor of gluconeogenesis.
CAS：320386-54-7
分子式：C6H5NO2S.HCl
分子量：191.6
纯度：98%
存储：Store at -20°C

Background:

3-Mercaptopicolinic acid is an inhibitor of gluconeogenesis. In perfused rat livers, gluconeogenesis was inhibited when lactate, pyruvate, or alanine served as substrate, but not with fructose, suggesting phosphoenolpyruvate carboxykinase as the site of inhibition.[1][2][3]

Reference:
[1]. DiTullio, N.W., Berkoff, C.E., Blank, B., et al. 3-mercaptopicolinic acid, an inhibitor of gluconeogenesis. Biochem. J. 138(3), 387-394 (1974).
[2]. Robinson, B.H., and Oei, J. 3-Mercaptopicolinic acid, a preferential inhibitor of the cytosolic phosphoenolpyruvate carboxykinase. FEBS Lett. 58(1), 12-15 (1975).
[3]. Hidalgo, J., Latorre, P., Carrodeguas, J.A., et al. Inhibition of pig phosphoenolpyruvate carboxykinase isoenzymes by 3-mercaptopicolinic acid and novel inhibitors. PLoS One 11(7), e0159002 (2016).