Phthalic acid mono-2-ethylhexyl ester (MEHP) 是邻苯二甲酸二己酯 (DEHP) 的主要生物活性代谢物,可抑制 CYP17 的 17,20 裂合酶活性。
CAS:4376-20-9
分子式:C16H22O4
分子量:278.34
纯度:98%
存储:Store at -20°C
Background:
Phthalic acid mono-2-ethylhexyl ester (MEHP) is a major bioactive metabolite of diethylhexyl phthalate (DEHP), which inhibits the 17, 20 lyase activity of CYP17[1].
[1]. Bai J, et al. Mono-2-ethylhexyl phthalate induces the expression of genes involved in fatty acid synthesis in HepG2 cells. Environ Toxicol Pharmacol. 2019 Jul;69:104-111.
[2]. ChauvignÉ F, et al. Mono-(2-ethylhexyl) phthalate directly alters the expression of Leydig cell genes and CYP17 lyase activity in cultured rat fetal testis. PLoS One. 2011;6(11):e27172.