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MCHr1 antagonist 2
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
MCHr1 antagonist 2图片
CAS NO:863115-70-2
规格:98%
分子量:424.42
包装与价格:
包装价格(元)
1mg电议
5mg电议
10mg电议

产品介绍
MCHr1antagonist2是一种黑色素聚集激素受体1(melaninconcentratinghormonereceptor1)拮抗剂,IC50值为65nM;MCHr1antagonist2同时抑制hERG,在IMR-32细胞中,IC50值为4.0nM。
CAS:863115-70-2
分子式:C23H21FN2O5
分子量:424.42
纯度:98%
存储:Store at -20°C

Background:

MCHr1 antagonist 2 is an antagonist of melanin concentrating hormone receptor 1, with an IC50 of 65 nM; MCHr1 antagonist 2 also inhibits hERG, with an IC50 of 4.0 nM in IMR-32 cells.


MCHr1 antagonist 2 (Compound 30) is an antagonist of melanin concentrating hormone receptor 1, with an IC50 of 65 nM. MCHr1 antagonist 2 has inhibitory effects on Ca2+ flux, and hERG, with IC50s of 196 ± 30 nM and 4.0 ± 0.8 nM, respectively, in IMR-32 cells[1].



[1]. Lynch JK, et al. Optimization of chromone-2-carboxamide melanin concentrating hormone receptor 1 antagonists: assessment of potency, efficacy, and cardiovascular safety. J Med Chem. 2006 Nov 2;49(22):6569-84.