Taurolithocholic acid (TLCA) is a taurine-conjugated form of the secondary bile acid lithocholic acid.
CAS：6042-32-6
分子式：C26H44NO5S.Na
分子量：505.7
纯度：98%
存储：Store at -20°C

Background:

Taurolithocholic acid (TLCA) is a taurine-conjugated form of the secondary bile acid lithocholic acid . TLCA (75 μM) increases caspase-3 and -7 activity in Hep3B cells transfected with sodium taurocholate cotransporting peptide (NTCP), but not nontransfected Hep3B cells. It has been used to induce cholestasis in ex vivo and in vivo animal models of hepatocellular cholestasis. Serum levels of TLCA increase approximately 5-fold in within two hours during an oral lipid tolerance test in humans.