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MCTR2
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
MCTR2图片
CAS NO:1784701-62-7
规格:98%
分子量:520.7
包装与价格:
包装价格(元)
10ug电议
25ug电议
50ug电议
100ug电议

产品介绍
Maresin conjugates in tissue regeneration 2 (MCTR2) is a specialized pro-resolving mediator (SPM) synthesized from docosahexaenoic acid in macrophages at the site of inflammation.
CAS:1784701-62-7
分子式:C27H40N2O6S
分子量:520.7
纯度:98%
存储:Store at -20°C

Background:

Maresin conjugates in tissue regeneration 2 (MCTR2) is a specialized pro-resolving mediator (SPM) synthesized from docosahexaenoic acid in macrophages at the site of inflammation. DHA is oxidized to maresin 1 , which is converted to MCTR1 by glutathione S-transferase Mu 4 or leukotriene C4 synthase then to MCTR2 by γ-glutamyl transferase. MCTR2 accelerates tissue regeneration in planaria (1 and 100 nM). Pretreatment with MCTR2 prior to E. coli administration reduces neutrophil infiltration, shortens the inflammatory resolution period, and increases phagocytosis of E. coli by macrophages. When administered at a dose of 100 ng 12h post E. coli infection in a mouse model of peritonitis, MCTR2 selectively reduced the amount of the eicosanoids PGD2 and PGF2α in the exudate.