Sumanirole maleate(PNU 95666E; U95666E) is a highly selective D2 receptor full agonist with an ED50 of about 46 nM.
CAS：179386-44-8
分子式：C15H17N3O5
分子量：319.31
纯度：98%
存储：Store at -20°C

Background:

Sumanirole maleate(PNU 95666E; U95666E) is a highly selective D2 receptor full agonist with an ED50 of about 46 nM.IC50 value: 46 nM (EC50)Target: D2 receptorSumanirole was developed for the treatment of Parkinson’s disease and restless leg syndrome. While it has never been approved for medical use. Sumanirole is a highly valuable tool compound for basic research to identify neurobiological mechanisms that are based on a dopamine D2-linked (vs. D1, D3, D4, and D5-linked) mechanism of action.

[1]. Arthur G. Romero, et al. Synthesis of the Selective D2 Receptor Agonist PNU-95666E fromD-Phenylalanine Using a Sequential Oxidative CyclizationStrategy. J. Org. Chem. 1997, 62, 6582-6587