Madrasin is a potent and cell penetrant splicing inhibitor that interferes with the early stages of spliceosome assembly.
CAS：374913-63-0
分子式：C16H17N5O2
分子量：311.34
纯度：98%
存储：Store at -20°C

Background:

Madrasin is a potent and cell penetrant splicing inhibitor that interferes with the early stages of spliceosome assembly. Madrasin is cytotoxic at higher concentrations, although at lower concentrations it induces cell cycle arrest, promotes a specific reorganization of subnuclear protein localization, and modulates splicing of multiple pre-mRNAs in both HeLa and HEK293 cells.

参考文献:
[1]. Andrea Pawellek et al. Identification of Small Molecule Inhibitors of Pre-mRNA Splicing. J Biol Chem, 2014 Dec 12, 289(50): 34683-34698.