BMP-1/PCP inhibitor,potent and selective
CAS：348622-88-8
分子式：C15H24N4O4
分子量：324.38
纯度：98%
存储：Store at -20°C

Background:

UK 383367 is a novel procollagen C-protein (PCP) inhibitor being investigated for the treatment of post-surgical dermal scarring, which potently inhibits the activity of PCP with the value of 50% inhibition concentration IC₅₀of 44 nM, as well as a selective inhibitor of matrix metalloproteinases (MMPs) with values of IC₅₀>60,000 nM for MMP-2 and >10,000 nM for MMP-1, MMP-3, MMP-9 and MMP-4. Although the mechanism is not clear yet, UK 383367 also exhibits weak inhibitory effects against phosphodiesterase-4 (PDE-4) enzyme, including PDE-4a, PDE-4b, PDE-4c and PDE-4d, with values of IC₅₀of 1.8 μM, 1.5 μM, 2.4 μM and 0.9 μM respectively.

Reference

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[2].Bailey S, Fish PV, Billotte S, Bordner J, Greiling D, James K, McElroy A, Mills JE, Reed C, Webster R.ff. Succinyl hydroxamates as potent and selective non-peptidic inhibitors of procollagen C-proteinase: design, synthesis, and evaluation as topically applied, dermal anti-scarring agents. Bioorg Med Chem Lett. 2008;18(24):6562-6567