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5'-deoxy Thymidine
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
5'-deoxy Thymidine图片
CAS NO:3458-14-8
规格:98%
分子量:226.2
包装与价格:
包装价格(元)
1mg电议
5mg电议
10mg电议

产品介绍
antibacterial activity
CAS:3458-14-8
分子式:C10H14N2O4
分子量:226.2
纯度:98%
存储:Store at -20°C

Background:

5'-Deoxy Thymidine has been used as a research tool for antiviral and anticancer studies. 5'-Deoxy Thymidine can be used to study the entry mechanism into human erythrocytes in comparison with other deoxythymidines. Deoxythymidine, also named as thymidine, is the DNA nucleoside T. Deoxythymidine can pair with deoxyadenosine (A) in double-stranded DNA. 5'-deoxy Thymidine is a form of thymidine which had the hydroxyl group at the 5' position replaced with hydrogen [1]. 5'-deoxy Thymidine (50 μg/mL) was effective against Bacillus subtilis and Staphylococcus aureus [1]. The MBC of 5'-deoxy Thymidine was 50 μg/mL. 5'-deoxy Thymidine has been used as an antibacterial agent in medical situations [1].


Thymidine has been phosphorylated at the hydroxyl group on carbon 5 of the ribose moiety before polymerization into DNA. 5'-Deoxy Thymidine cannot be phosphorylated and used by DNA polymerase in the synthesis of DNA. In human erythrocytes, 5'-Deoxy Thymidine was readily and nonconcentratively uptaked by metabolism, and could be partially inhibited by nucleosides or inhibitors of nucleoside transport at micromolar concentrations [2].


参考文献:
[1] Hatano A, Nishimura M, Souta I.  Impact of unnatural nucleosides on the control of microbial growth[J]. Biocontrol science, 2009, 14(2): 55-60.
[2] Domin B A, Mahony W B, Koszalka G W, et al.  Membrane permeation characteristics of 5'-modified thymidine analogs[J]. Molecular pharmacology, 1992, 41(5): 950-956.