Background:

Meropenem trihydrate (SM-7338) is an active ingredient carbapenem antibiotic [1].

Meropenem trihydrate has shown the potent effect against gram-negative organisms with the MIC90 values of 0.03μM, 0.06μM, 0.06μM, 0.12μM,0.25μM, 0.12μM, 0.06μM, 0.12μM and 0.25μM for Escherichia coli (30), Klebsiella pneumonia(29), Klebsiella oxytoca (20), Enterobacter aerogenes (14), Enterobacter cloacae (29), Citrobacter freundii (20), Citrobacter diversus (12), proteus mirabilis (15) and Morganella morganii (15), respectively. In addition, Meropenem trihydrate has also been revealed to restrain gram-positive and anaerobic organisms with the MIC90 values of 0.008μM, 4μM and 0.015μM for Streptococcus pyogenes (20), Viridans group streptococci (27), Streptococcus pneumonia (15), respectively. Furthermore, Meropenem trihydrate has shown the different effect of pH on MIC, for example, the mean MIC values of 0.06μM and 0.03μM in pH5.5 and pH7.5, respectively [1].

参考文献:
[1] Neu HC1, Novelli A, Chin NX.In vitro activity and beta-lactamase stability of a new carbapenem, SM-7338.Antimicrob Agents Chemother. 1989 Jul; 33(7):1009-18.