Flunisolide是一种皮质类固醇,常用于治疗过敏性鼻炎。Flunisolide的主要作用机制是激活糖皮质激素受体,意味着它具有抗炎作用。
CAS：3385-03-3
分子式：C24H31FO6
分子量：434.5
纯度：98%
存储：Store at -20°C

Background:

Flunisolide is a fluorinated corticosteroid receptor agonist that induces reversible pyloric hyalinization in CD-1 mice following oral administration at a dose of 200 μg/kg per day.[1] Formulations containing flunisolide have been used for the treatment of asthma.[2]

Reference:
[1]. McKevitt, T.P., Giffen, P., Woodfine, J.A., et al. Hyalinization of the pyloric stomach in CD-1 mice following oral (dietary) administration of the corticosteroid agonists mometasone furoate, budesonide, and flunisolide. Toxicol. Pathol. 39(6), 958-968 (2011).
[2]. O'Callaghan, C., White, J.A., and Kantar, A. Nebulization of corticosteroids to asthmatic children: Large variation in dose inhaled. Respirology 19(2), 276-279 (2014).