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5-trans Latanoprost(free acid)
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
5-trans Latanoprost(free acid)图片
CAS NO:903549-49-5
规格:98%
分子量:390.5
包装与价格:
包装价格(元)
1mg电议
5mg电议
10mg电议

产品介绍
Latanoprost is an F-series prostaglandin (PG) analog which has been approved for use as an ocular hypotensive drug.
CAS:903549-49-5
分子式:C23H34O5
分子量:390.5
纯度:98%
存储:Store at -20°C

Background:

Latanoprost is an F-series prostaglandin (PG) analog which has been approved for use as an ocular hypotensive drug. Latanoprost is an isopropyl ester, a prodrug form which is converted to latanoprost (free acid) by endogenous esterase enzymes. The free acid form is 200 times more potent than latanoprost as a ligand for the human recombinant FP receptor. 5-trans Latanoprost (free acid) is an isomer of latanoprost (free acid) wherein the double bond between carbons 5 and 6 has been changed from cis (Z) to trans (E). The trans isomer of latanoprost occurs as an impurity in commercial preparations of the bulk drug product. The present compound was prepared primarily as an analytical standard for detection and quantitation of this impurity. From what can be inferred from the study of other trans isomers of F-type prostaglandins, the biological activity of this isomer is likely to be similar to that of the cis isomer. However, there are no specific published reports on the biological activity, and on reducing intraocular pressure in particular, of 5-trans latanoprost.