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DFMTI(MK5435)
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
DFMTI(MK5435)图片
CAS NO:864864-86-8
规格:98%
分子量:368.38
包装与价格:
包装价格(元)
1mg电议
5mg电议
10mg电议
50mg电议
100mg电议

产品介绍
DFMTI能够完全阻止rmGlu1L757V谷氨酸反应。
CAS:864864-86-8
分子式:C20H18F2N4O
分子量:368.38
纯度:98%
存储:Store at -20°C

Background:

DFMTI can completely block the rmGlu1 L757V glutamate response.In vitro: DFMTI can completely block the rmGlu1 L757V glutamate response, although significantly higher concentrations were required to induce blockade.In vivo: DFMTI is efficacious in disrupting prepulse inhibition when dosed orally in rats. DFMTI exhibits a moderate decrease in human potency of approximately 3-fold when compared to rat, exemplified by DFMTI.




[1]. Cho HP et al. A novel class of succinimide-derived negative allosteric modulators of metabotropic glutamate receptor subtype 1 provides insight into a disconnect in activity between the rat and human receptors. ACS Chem Neurosci. 2014 Jul 16;5(7):597-610.