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Terbinafine
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Terbinafine图片
CAS NO:91161-71-6
规格:98%
分子量:291.43
包装与价格:
包装价格(元)
100mg电议
200mg电议

产品介绍
Allylamine antifungal agent
CAS:91161-71-6
分子式:C21H25N
分子量:291.43
纯度:98%
存储:Store at -20°C

Background:

Terbinafine (TDT 067) is an antifungal medication used to treat fungal infections. It is a potent non-competitive inhibitor of squalene epoxidase from Candida with a Ki of 30 nM.


Terbinafine has a primary fungicidal action in vitro against most fungal pathogens, including dermatophytes, and dimorphic and filamentous fungi. Terbinafine specifically inhibits fungal ergosterol biosynthesis at the point of squalene epoxidation. The treated fungal cells rapidly accumulate tlic intermediate squalene and become deficient in the end-product of the pathway, ergosterol[1].


Terbinafine is not only active after topical application but is very effective in experimental dermatophytoses following oral administration. In fungi infected guinea-pigs, the skin temperature dropps dramatically after the fourth treatment of terbinafine[2].


参考文献:
[1]. Ryder NS, et al. Terbinafine: mode of action and properties of the squalene epoxidase inhibition. Br J Dermatol. 1992 Feb;126 Suppl 39:2-7.
[2]. Mieth H, et al. Preclinical evaluation of terbinafine in vivo. Clin Exp Dermatol. 1989 Mar;14(2):104-7.