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48740 RP(RP-55778)
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
48740 RP(RP-55778)图片
CAS NO:93363-11-2
规格:98%
分子量:245.3
包装与价格:
包装价格(元)
1mg电议
5mg电议
10mg电议

产品介绍
48740RP是一种血小板激活因子(PAF)拮抗剂。
CAS:93363-11-2
分子式:C12H11N3OS
分子量:245.3
纯度:98%
存储:Store at -20°C

Background:

48740 RP is a platelet-activating factor (PAF) antagonist.



48740 RP is a platelet-activating factor (PAF) antagonist. In animals treated with 48740 RP only, the number of platelets is increased at a time corresponding to 2 and 4 h after the exposure to lipopolysaccharide (LPS) and the number of eosinophils is also slightly increased. Treatment with 48740 RP in combination with the LPS exposure does not influence the increase in neutrophils seen 2 and 4 h after exposure. At 24 h the increase in the number of neutrophils is about half that in control animals. No effects are found on the LPS-induced increase in number of platelets. In animals pretreated with 48740 RP, there is a significant reduction in capillary permeability[1].


[1]. Rylander R, et al. Modulation of pulmonary inflammation after endotoxin inhalation with a platelet-activating factor antagonist (48740 RP). Int Arch Allergy Appl Immunol. 1988;86(3):303-7.