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FKK
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
FKK图片
CAS NO:78299-79-3
规格:98%
分子量:329.23
包装与价格:
包装价格(元)
1mg电议
5mg电议
10mg电议

产品介绍
FKK是一种吲唑衍生物,也是一种新型支气管扩张剂。
CAS:78299-79-3
分子式:C17H17BrN2
分子量:329.23
纯度:98%
存储:Store at -20°C

Background:

FKK is an indazole derivative and also a novel bronchodilator.



FKK is an indazole derivative and also a novel bronchodilator. FKK (0.1 to 3.0 mg/kg, i.v.) slightly increases respiratory frequency, left ventricular (LV) dp/dt max and myocardial contractile force. A slight increase followed by a decrease is observed in systemic blood pressure and LV systolic pressure. FKK causes direct vasodilation in the coronary, mesenteric and femoral vasculatures, but has no effect on the renal vasculature. It is particularly pertinent that FKK (30 mg/kg, i.d., enough to cause marked bronchodilation), unlike aminophylline (30 mg/kg, i.d.), does not significantly influence the cardiovascular system[1].


[1]. Shiraki Y, et al. Effects of an indazole derivative, FKK, a novel bronchodilator, on the cardiovascular system in dogs. Arch Int Pharmacodyn Ther. 1985 Jan;273(1):155-66.