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Coixol(6-Methoxy-2-benzoxazolinone)
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Coixol(6-Methoxy-2-benzoxazolinone)图片
CAS NO:532-91-2
规格:98%
分子量:165.15
包装与价格:
包装价格(元)
5mg电议
10mg电议

产品介绍
薏苡内酯(Coixol)是一种天然化合物。
CAS:532-91-2
分子式:C8H7NO3
分子量:165.15
纯度:98%
存储:Store at -20°C

Background:

Coixol is a natural product extracted from Coix Lachryma-Jobi var. ma-yuen.IC50 value:Target:In vitro: Confluent NCI-H292 cells were pretreated with oleic acid, linoleic acid, glyceryl trilinoleate, beta-stigmasterol or coixol for 30 min and then stimulated with PMA (phorbol 12-myristate 13-acetate), EGF (epidermal growth factor) or TNF-α (tumor necrosis factor-α) for 24 h. Coixol inhibited the expression of MUC5AC mucin gene and production of MUC5AC mucin protein, induced by EGF or TNF-α from NCI-H292 cells; Coixol decreased PMA-induced MUC5AC mucin secretion from NCI-H292 cells [1]. βTC-6 cells were incubated in 2 mM and 20 mM glucose in thepresence of coixol (200 μM) for 60 min at 37°C in Krebs-RingerBicarbonate buffer. Decreased insulin staining was observed by coixol at 20 mM glucose (bottom) suggest that coixol stimulated insulin secretion at high glucose concentration [2].In vivo:




[1]. Lee HJ, et al. Suppressive effects of coixol, glyceryl trilinoleate and natural products derived from Coix Lachryma-Jobi var. ma-yuen on gene expression, production and secretion of airway MUC5AC mucin. Arch Pharm Res. 2015;38(5):620-7. [2]. Rahman M Hafizur, et al. Coixol Exerts an Exclusive Glucose-dependent Insulinotropic Effect in βTC-6Cells. Hafizur et al., J Cytol Histol 2015, 6:3