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Pyr10
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Pyr10图片
CAS NO:1315323-00-2
规格:98%
分子量:449.37
包装与价格:
包装价格(元)
5mg电议
10mg电议
50mg电议

产品介绍
Pyr10是一种新型TRPC3选择性抑制剂,作用于转染YFP-TRPC3的HEK293细胞,抑制ROCE,IC50为0.72uM。
CAS:1315323-00-2
分子式:C18H13F6N3O2S
分子量:449.37
纯度:98%
存储:Store at -20°C

Background:

Pyr10is a novel TRPC3-selective inhibitor, IC50 of Ca2+ influx inhibition by Pyr10 in carbachol-stimulated YFP-TRPC3-transfected HEK293 cells for ROCE and thapsigargin-depleted native RBL-2H3 cells for SOCE is 0.72 uM and 13.08 uM.IC50 value: 0.72 uM (TRPC3-ROCE), 13.08 uM (SOCE) [1]Target: TRPC3in vitro: Pyr10 displays substantial selectivity for TRPC3-mediated responses (18-fold) and the selective block of TRPC3 channels by Pyr10 barely affected mast cell activation.[1]




[1]. Schleifer H, et al. Novel pyrazole compounds for pharmacological discrimination between receptor-operated and store-operated Ca(2+) entry pathways. Br J Pharmacol. 2012 Dec;167(8):1712-1722. [2]. Obermayer D, et al. Microwave-assisted and continuous flow multistep synthesis of 4-(pyrazol-1-yl)carboxanilides. J Org Chem. 2011 Aug 19;76(16):6657-6669.