SL 01 is a prodrug of gemcitabine, the nucleoside analog used intravenously to treat various cancers that was designed for improved oral bioavailability.
CAS：26049-94-5
分子式：C18H18ClNO3
分子量：331.8
纯度：98%
存储：Store at -20°C

Background:

SL 01 is a prodrug of gemcitabine , the nucleoside analog used intravenously to treat various cancers that was designed for improved oral bioavailability. SL 01 can inhibit the growth of human non-small cell lung cancer NCI-H460 cells, colon cancer HCT116 cells, and breast cancer MCF-7 cells (IC50s = 0.78, 0.92, and 0.64 μM, respectively), inducing apoptosis. In nude mice bearing NCI-H460, HCT116, or MCF-7 cancer cell xenografts, SL 01 at 10-50 μM/kg has been shown to delay tumor growth.