PHPS1 is a cell-permeable, phosphotyrosine mimetic that inhibits the Src homology region 2 domain-containing phosphatase (SHP)-2 (IC50 = 2.1 μM; Ki = 0.73 μM).
CAS：314291-83-3
分子式：C21H15N5O6S
分子量：465.4
纯度：98%
存储：Store at -20°C

Background:

PHPS1 is a cell-permeable, phosphotyrosine mimetic that inhibits the Src homology region 2 domain-containing phosphatase (SHP)-2 (IC50 = 2.1 μ Ki = 0.73 &#181M). It is selective for SHP-2, inhibiting ECPTP, PTP1B, SHP-1, and mycobacterium MptpA at relatively higher concentrations (IC50s = 5.4, 19, 30, and 39 &#181M, respectively). PHPS1 has been shown to inhibit SHP-2-dependent cellular signaling and tumor cell colony formation.

Reference:
[1]. Hellmuth, K., Grosskopf, S., Lum, C.T., et al. Specific inhibitors of the protein tyrosine phosphatase Shp2 identified by high-throughput docking. Proceedings of the National Academy of Sciences of the United States of America 105(20), 7275-7280 (2008).