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Mefruside
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
CAS NO:7195-27-9
包装:50mg, 100mg, 250mg
规格:≥98%

产品介绍

Mefruside is a diuretic indicated for the treatment of edema and hypertension. References: el Walily AF. Simultaneous determination of the binary mixture of nifedipine and mefruside using derivate spectroscopy, capillary gas-liquid chromatography and high performance liquid chromatography. Acta Pharm Hung. 1997 Mar-May;67(2-3):89-97. PubMed PMID: 9223759. 2: Landmark K, Forsman M, Lindberg K, Ryman T, Martmann-Moe K, Haaverstad S, Wiel S. Nitrendipine and mefruside in elderly hypertensives: effects on blood pressure, cardiac output, cerebral blood flow and metabolic parameters. J Hum Hypertens. 1995 Apr;9(4):281-5. PubMed PMID: 7595911. 3: Hofling B, Haringer E, Herrmann W, Pieske H, Pieske R, Philippi M. [Therapy of mild to moderate hypertension. Efficacy and tolerance of Amlodipine in comparison with the combination nifedipine/mefruside]. Fortschr Med. 1991 May 20;109(15):327-30. German. PubMed PMID: 1830287. 4: Kirsten R, Heller A, Heintz B, Nelson K. Influence of co-dergocrine mesilate/nifedipine compared to mefruside/nifedipine on circadian blood pressure in patients with essential hypertension. J Hum Hypertens. 1990 Aug;4(4):461-4. PubMed PMID: 2258894. 5: Notghi A, Anderton JL. Effect of nifedipine and mefruside on renal reserve in hypertensive patients. Postgrad Med J. 1988 Nov;64(757):856-9. PubMed PMID: 3255934; PubMed Central PMCID: PMC2429038. 6: Schulte KL, Meyer-Sabellek W, Rocker L, Gotzen R, Distler A. Effects of diltiazem alone and combined with mefruside on cardiovascular response at rest and during exercise, carbohydrate metabolism and serum lipoproteins in patients with systemic hypertension. Am J Cardiol. 1987 Oct 1;60(10):826-31. PubMed PMID: 3661396. 7: Saito F, Kimura G, Shimozaki Y, Fujii T, Ishii T, Yoshida K, Abe H, Kawamura M, Deguchi F, Kawano Y, et al. [Mechanism of hypotensive action of a diuretic, mefruside, based on the pressure-natriuresis relationship]. Nihon Jinzo Gakkai Shi. 1987 Apr;29(4):461-7. Japanese. PubMed PMID: 3656703. 8: Notghi A, Fiskerstrand CE, Burnet ME, Anderton JL. Effect of nifedipine and mefruside on renal function and platelet function in hypertensive patients. Curr Med Res Opin. 1987;10(7):441-9. PubMed PMID: 3621989. 9: Poulter N, Thompson AV, Sever PS. A double-blind, placebo-controlled, crossover trial to investigate the additive hypotensive effect of a diuretic (mefruside) to that produced by nifedipine. J Cardiovasc Pharmacol. 1987;10 Suppl 10:S53-6. PubMed PMID: 2455140. 10: Junginger HE, Wedler M. Thermal stability of mefruside-polyvinylpyrrolidone solid dispersions. Pharm Res. 1986 Feb;3(1):41-4. doi: 10.1023/A:1016320831469. PubMed PMID: 24271355. 1 Buemi M, Macrì I, Ussi F, Frisina N. [A new guanabenz-mefruside drug in the treatment of arterial hypertension]. Minerva Cardioangiol. 1985 Jan-Feb;33(1-2):73-80. Italian. PubMed PMID: 4010975. 12: Schulte KL, Meyer-Sabellek W, Gotzen R. Effects of acebutolol combined with mefruside on total-body and serum potassium in essential hypertensive patients. Int J Clin Pharmacol Ther Toxicol. 1984 Aug;22(8):438-40. PubMed PMID: 6490227. 13: Douglas-Jones AP, Mitchell AD. Comparison of nifedipine (retard formulation) and mefruside in the treatment of mild to moderate hypertension--a prospective randomized double-blind crossover study in general practice. Postgrad Med J. 1984 Aug;60(706):529-32. PubMed PMID: 6382224; PubMed Central PMCID: PMC2417958. 14: Tomasi AM, Pirani R, Masoni C. [Treatment of idiopathic hypertension with guanabenz-mefruside]. Minerva Cardioangiol. 1984 May;32(5):339-44. Italian. PubMed PMID: 6382059. 15: Frisina N, Macrì I, Ussi F. [Treatment of arterial hypertension with a new drug combining guanabenz-mefruside]. Minerva Cardioangiol. 1984 May;32(5):325-32. Italian. PubMed PMID: 6382057. 16: Fleuren HL, Verwey-Van Wissen CP, Van Rossum JM. Quantitative gas chromatographic determination of two oxidized metabolites of the diuretic mefruside in human urine, plasma and red blood cells. J Chromatogr. 1980 May 9;182(2):179-90. PubMed PMID: 7380910. 17: Henningsen NC, Bergengren B, Malmborg O, Pihl O, Renmarker K, Strand L. Effects of mefruside treatment in hypertension. Acta Med Scand. 1980;208(4):272-8. PubMed PMID: 7446207. 18: Seedat YK. An evaluation of debrisoquine and mefruside in the treatment of hypertension in African and Indian patients. Curr Med Res Opin. 1980;7(1):68-72. PubMed PMID: 7428417. 19: Fleuren HL, Verwey-van Wissen CP, van Rossum JM. Pharmacokinetics of mefruside and two active metabolites in man. Eur J Clin Pharmacol. 1980 Jan;17(1):59-69. PubMed PMID: 7371701. 20: Fleuren HL, Verwey-van Wissen CP, van Rossum JM. Quantitative gas chromatographic determination of mefruside in body fluids by extractive methylation and nitrogen detection. Arzneimittelforschung. 1979;29(7):1041-7. PubMed PMID: 582996.

纯度:≥98%

CAS:7195-27-9