OsteogenicGrowthPeptide,OGP是由14个氨基酸残基组成的多肽，是一种对骨髓损伤有系统性应答的促进因子，以μM级浓度存在于哺乳动物的血清中。
CAS：132996-61-3
分子式：C68H110N22O18
分子量：1523.74
纯度：98%
存储：Store at -20°C

Background:

Osteogenic Growth Peptide, OGP is a short, naturally occurring 14-mer growth factor peptide found in serum at μM concentrations.

Osteogenic Growth Peptide (OGP) regulates proliferation, differentiation, and matrix mineralization in osteoblast lineage cells. The active portion of OGP, the OGP(10-14) region, is cleaved from the peptide and binds to the OGP receptor which activates the MAP kinase, the Src, and the RhoA pathways[1]. Osteogenic Growth Peptide (OGP) is a native molecule with a primary structure identical to the C-terminus of histone H4, whose sequence contains a highly conserved 14-amino acid motif (NH2-ALKRQGRTLYGFGG-OH). This peptide is isolated from blood during osteogenic remodeling of post-ablation of marrow regeneration. The osteogenic growth peptide (OGP) and its C-terminal pentapeptide OGP(10-14) have been shown to stimulate the proliferation, differentiation, alkaline phosphatase activity and matrix mineralization of osteoblastic lineage cells[2].

[1]. Moore NM, et al. The use of immobilized osteogenic growth peptide on gradient substrates synthesized via clickchemistry to enhance MC3T3-E1 osteoblast proliferation. Biomaterials. 2010 Mar;31(7):1604-11. [2]. Pigossi SC, et al. Role of Osteogenic Growth Peptide (OGP) and OGP(10-14) in Bone Regeneration: A Review. Int J Mol Sci. 2016 Nov 22;17(11). pii: E1885.