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URMC-099
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
URMC-099图片
CAS NO:1229582-33-5
包装与价格:
包装价格(元)
5mg电议
10mg电议
25mg电议
10mM * 1mL in DMSO电议

产品名称
URMC 099,URMC099
产品介绍

生物活性

URMC-099是生物利用的脑渗透混合谱系激酶(MLK)抑制剂,对于MLK1,MLK2,MLK3和DLK,IC50分别为19 nM,42 nM,14 nM和150 nM。

Targets

TargetValue
Abl1IC50: 6.5nM
LRRK2IC50: 11nM
MLK3IC50: 14nM
MLK1IC50: 19nM
VEGFR1/FLT1IC50: 39nM
MLK2IC50: 42nM
SGKIC50: 67nM
TrkAIC50: 85nM
AuroraAIC50: 108nM
ROCK2IC50: 111nM
AuroraBIC50: 123nM
DLKIC50: 150nM
c-MetIC50: 177nM
IRIC50: 200nM
SGK1IC50: 201nM
TrkBIC50: 217nM
AuroraCIC50: 290nM
IGF-1RIC50: 307nM
LCKIC50: 333nM
MEKK2IC50: 661nM
SykIC50: 731nM
ROCK1IC50: 1030nM
CDK1IC50: 1125nM
CDK2IC50: 1180nM
AMPKIC50: 1512nM
JNK1IC50: 3280nM
SrcIC50: 4330nM
ZAP70IC50: 5050nM
ERK2IC50: 6290nM
GSK-3βIC50: >10000nM
p38αIC50: 12050nM

化学数据

目录号A14219
作用机制Inhibitor (抑制剂)
M. Wt421.54
FormulaC27H27N5
Purity>99%
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for36 months.
In solution, store at -20ºC and use within3 monthsto prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

CAS No.1229582-33-5
SynonymsURMC 099,URMC099
SMILESCN1CCN(CC1)CC2=CC=C(C=C2)C3=CN=C4C(=C3)C(=CN4)C5=CC6=C(C=C5)NC=C6

溶解度

In vitroDMSO76 mg/mL (180.28 mM)
WaterInsoluble
Ethanol5 mg/mL (11.86 mM)
*<1 mg/ml means slightly soluble or insoluble.
*Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

储备液配制

Concentration / Solvent Volume / Mass1 mg5 mg10 mg
0.1 mM23.72 mL118.61 mL237.23 mL
0.5 mM4.74 mL23.72 mL47.45 mL
1 mM2.37 mL11.86 mL23.72 mL
5 mM0.47 mL2.37 mL4.74 mL

*The above data is based on the productmolecular weight 421.54. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.