Vicagrel 氯吡格雷的醋酸衍生物，是一种 P2Y12 血小板抑制剂，可用于治疗血栓形成，羧酸酯酶 2 (CES2) 的底物。Vicagrel 具有良好的安全性和优异的抗血小板活性，可作为抗血小板药物。
CAS：1314081-53-2
分子式：C18H18ClNO4S
分子量：379.86
纯度：98%
存储：Store at -20°C

Background:

Vicagrel, an acetate derivative of Clopidogrel, is a P2Y12 platelet inhibitor potentially for the treatment of thrombosis, the substrate of carboxylesterase 2 (CES2)[1]. Vicagrel demonstrates a favorable safety profile and excellent anti-platelet activity, which could be an anti-platelet drug and for the unmet medical needs of cardiovascular diseases[2].

[1]. Liu C, et al. Pharmacokinetics and pharmacokinetic/pharmacodynamic relationship of vicagrel, a novel thienopyridine P2Y12 inhibitor, compared with clopidogrel in healthy Chinese subjects following single oral dosing. Eur J Pharm Sci. 2019 Jan 15;127:151-160. [2]. Li X, et al. Evaluation of Tolerability, Pharmacokinetics and Pharmacodynamics of Vicagrel, a Novel P2Y12 Antagonist, in Healthy Chinese Volunteers. Front Pharmacol. 2018 Jun 20;9:643.