ML-792 是一种特异性的小泛素样修饰物 (SUMO) 活化酶 (SAE) 抑制剂。ML-792 有效选择性抑制 SAE/SUMO1 和 SAE/SUMO2，IC50 分别为 3 和 11 nM。ML-792 微弱抑制 NAE/NEDD8 和 UAE/ubiquitin，IC50 分别为 32 μM 和 >100 μM。
CAS：1644342-14-2
分子式：C21H23BrN6O5S
分子量：551.41
纯度：98%
存储：Store at -20°C

Background:

ML-792 is a specific small ubiquitin-like modifier (SUMO)-activating enzyme (SAE) inhibitor. ML-792 is a potent and selective inhibitor of SAE/SUMO1 and SAE/SUMO2 in enzymatic assays (IC50s of 3 and 11 nM, respectively) compared with NAE/NEDD8 and UAE/ubiquitin (IC50s of 32 μM and >100 μM, respectively)[1].

[1]. He X, et al. Probing the roles of SUMOylation in cancer cell biology by using a selective SAE inhibitor. Nat Chem Biol. 2017 Nov;13(11):1164-1171.