Desaminotyrosine是一种微生物相关的代谢物，通过扩大I型干扰素(typeIinterferon)信号来阻止influenza的发生。
CAS：501-97-3
分子式：C9H10O3
分子量：166.18
纯度：98%
存储：Store at -20°C

Background:

Desaminotyrosine is a microbially associated metabolite protecting from influenza through augmentation of type I interferon signaling.

Wild-type mice produce nanomoles of Desaminotyrosine per gram of feces and have picomolar quantities of Desaminotyrosine in the serum. Desaminotyrosine (200 mM) treatment before influenza infection, protects from influenza by type I interferon (IFN) signaling, with no effect on weight loss or survival in mice with or without vancomycin, neomycin, ampicillin, and metronidazole (VNAM). Desaminotyrosine enhances type I IFN in macrophages via type I IFN amplification in mice[1].

[1]. Steed AL, et al. The microbial metabolite desaminotyrosine protects from influenza through type I interferon. Science. 2017 Aug 4;357(6350):498-502.