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Bergaptol(5-Hydroxypsoralen)
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Bergaptol(5-Hydroxypsoralen)图片
CAS NO:486-60-2
包装:500mg
规格:98%
市场价:1823元
分子量:202.16

产品介绍
Bergaptol是CYP3A4酶脱苄基作用的抑制剂,它的IC50是24.92uM.最近的研究表明它有抗增殖和抗癌性。
CAS:486-60-2
分子式:C11H6O4
分子量:202.16
纯度:98%
存储:Store at -20°C

Background:

BergaptolA hydroxylated psoralen that acts as a potent inhibitors of debenzylation activity of CYP3A4 enzyme with an IC50 value of 24.92 uM. Recent studies suggest that it may have antiproliferative and anticancer properties.target: CYP3A4 [1]IC50: 24.92 [1]For in vivo enzyme activity analysis, 100 μM bergaptol was added to the cultures for an additional 24 h at 37°C. After centrifugation, the supernatant was used to measure the bergapten yield by high performance liquid chromatography (HPLC).[2]




[1]. Basavaraj Girennavar et al. Radical scavenging and cytochrome P450 3A4 inhibitory activity of bergaptol and geranylcoumarin from grapefruit. Bioorganic & Medicinal Chemistry.June 2007, Pages 3684-3691 [2]. Yucheng Zhao et al. Cloning, Functional Characterization, and Catalytic Mechanism of a Bergaptol O-Methyltransferase from Peucedanum praeruptorum Dunn. Front Plant Sci, 2016, 7: 722.