MK-3328是一种β-淀粉样蛋白(β-Amyloid)PET配体，具有高的结合效力，IC50为10.5nM。
CAS：1201323-97-8
分子式：C14H9FN4O
分子量：268.25
纯度：98%
存储：Store at -20°C

Background:

MK-3328 is a β-Amyloid PET ligand, which exhibits high binding potency with an IC50 of 10.5 nM.

MK-3328 exhibits amyloid binding potency balanced with low levels of nonspecific binding[1].

In vivo, [18F]MK-3328 demonstrates favorable kinetics, exhibiting high brain uptake and good washout in normal rhesus monkey positron emission tomography (PET) imaging studies[1].

[1]. Harrison ST, et al. Synthesis and Evaluation of 5-Fluoro-2-aryloxazolo[5,4-b]pyridines as β-Amyloid PET Ligands and Identification of MK-3328. ACS Med Chem Lett. 2011 Apr 18;2(7):498-502.