Latanoproste bunod is a nitric oxide-donating prostaglandin F2α (FP) receptor agonist that is converted to latanoprost (free acid) and nitric oxide (NO) in vivo.
CAS：860005-21-6
分子式：C27H41NO8
分子量：507.6
纯度：98%
存储：Store at -20°C

Background:

Latanoproste bunod is a nitric oxide-donating prostaglandin F2α (FP) receptor agonist that is converted to latanoprost (free acid) and nitric oxide (NO) in vivo. It induces cGMP accumulation in PC12 and HEK293 cells (EC50s = 1.6 and 9.2 μM, respectively). Topical administration of latanoprost bunod (0.036% solution) reduces intraocular pressure (IOP) in canine and rabbit models of glaucoma. It also decreases IOP in a cynomolgus monkey model of laser-induced ocular hypertension.