Cangrelor is an ATP analog that inhibits platelet aggregation (IC50 = 0.4 nM).
CAS:163706-36-3
分子式:C17H21Cl2F3N5O12P3S2.4Na
分子量:864.3
纯度:98%
存储:Store at -20°C
Background:
Cangrelor is an ATP analog that inhibits platelet aggregation (IC50 = 0.4 nM). It is a reversible competitive antagonist of the platelet purinergic P2Y12 receptor. Pretreatment with cangrelor significantly reduces blood clotting induced by ADP in a mouse model of pulmonary thromboembolism. Formulations containing cangrelor have been used to prevent blood clotting in at-risk patients.