ML-390 is an inhibitor of dihydroorotate dehydrogenase (DHODH)
CAS：2029049-79-2
分子式：C21H21F3N2O3
分子量：406.4
纯度：98%
存储：Store at -20°C

Background:

ML-390 is an inhibitor of dihydroorotate dehydrogenase (DHODH), the enzyme that converts dihydroorotate to orotate during de novo pyrimidine synthesis.1 In acute myeloid leukemia, leukemic myeloblast development is halted at an immature stage leading to perpetual self-renewal rather than differentiation. ML-390 induces differentiation in the acute myeloid leukemia cell lines U937 (murine) and THP-1 (human) cell lines with an EC50 value of approximately 2 μM.

Reference:

[1]. Sykes, D.B., Kfoury, Y.S., Mercier, F.E., et al. Inhibition of dihydroorotate dehydrogenase overcomes differentiation blockade in acute myeloid leukemia Cell. 167(1), 171-186 (2016).