您好,欢迎来到试剂信息网! [登录] [免费注册]
试剂信息网
位置:首页 > 产品库 > AC710
立即咨询
咨询类型:
     
*姓名:
*电话:
*单位:
Email:
*留言内容:
请详细说明您的需求。
*验证码:
 
AC710
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
AC710图片
CAS NO:1351522-04-7
规格:98%
分子量:562.7
包装与价格:
包装价格(元)
10mg电议
25mg电议
50mg电议
100mg电议

产品介绍
A potent and selective PDGFR family inhibitor
CAS:1351522-04-7
分子式:C31H42N6O4
分子量:562.7
纯度:98%
存储:Store at -20°C

Background:

AC710 is a potent, orally active, and selective platelet-derived growth factor receptor-family kinase inhibitor with potential anticancer activity. Its IC50 values are 1.2, 2, 7.7 and 10.5 nM for KIT, FLT3, PDGFRβ and CSF1R respectively; Kd = 1.3 nM for PDGFRα.. AC710 causes tumor regression of leukemia cell xenografts in mice. AC710 also reduces joint swelling and inflammation in a mouse model of collagen-induced arthritis. AC710 is now a preclinical development candidate.



REFERENCES:


Liu *??, Brian T. Campbell ??, Mark W. Holladay ??, Julia M. Ford Pulido ??, Helen Hua ??, Dana Gitnick , Michael F. Gardner , Joyce James , Mike A. Breider , Daniel Brigham ??, Barbara Belli ??, Robert C. Armstrong ??, and Daniel K. Treiber. Discovery of AC710, a Globally Selective Inhibitor of Platelet-Derived Growth Factor Receptor-Family Kinases. ACS Med. Chem. Lett., 2012, 3 (12), pp 997?–1002