CAS NO: | 1351522-04-7 |
规格: | 98% |
分子量: | 562.7 |
包装 | 价格(元) |
10mg | 电议 |
25mg | 电议 |
50mg | 电议 |
100mg | 电议 |
Background:
AC710 is a potent, orally active, and selective platelet-derived growth factor receptor-family kinase inhibitor with potential anticancer activity. Its IC50 values are 1.2, 2, 7.7 and 10.5 nM for KIT, FLT3, PDGFRβ and CSF1R respectively; Kd = 1.3 nM for PDGFRα.. AC710 causes tumor regression of leukemia cell xenografts in mice. AC710 also reduces joint swelling and inflammation in a mouse model of collagen-induced arthritis. AC710 is now a preclinical development candidate.
REFERENCES:
Liu *??, Brian T. Campbell ??, Mark W. Holladay ??, Julia M. Ford Pulido ??, Helen Hua ??, Dana Gitnick , Michael F. Gardner , Joyce James , Mike A. Breider , Daniel Brigham ??, Barbara Belli ??, Robert C. Armstrong ??, and Daniel K. Treiber. Discovery of AC710, a Globally Selective Inhibitor of Platelet-Derived Growth Factor Receptor-Family Kinases. ACS Med. Chem. Lett., 2012, 3 (12), pp 997?–1002