Tricothecene mycotoxin and potent protein synthesis inhibitor
CAS：51481-10-8
分子式：C15H20O6
分子量：296.32
纯度：98%
存储：Store at -20°C

Background:

4-deoxy Nivalenol is a natural type B trichothecene produced by certain species of the fungus Fusarium, particularly those found on cereal crops, including wheat, barley, oats, maize, and rye.[1],[2] This mycotoxin can induce vomiting, diarrhea, and weight loss as well as other physiological and toxicological effects.[3] It inhibits protein biosynthesis, binds to peptidyl transferase, and inhibits the synthesis of RNA and DNA, contributing to immunotoxicity.[4] It passes the blood-brain barrier at different rates in different animals and this may be related to anorexia.[3]

Reference:
[1]. Pestka, J.J., and Smolinski, A.T. Deoxynivalenol: Toxicology and potential effects on humans. J.Toxicol.Environ.Health B.Crit.Rev. 8(1), 39-69 (2005).
[2]. Maresca, M. From the gut to the brain: Journey and pathophysiological effects of the food-associated trichothecene mycotoxin deoxynivalenol. Toxins (Basel) 5(4), 784-820 (2013).
[3]. Bonnet, M.S., Roux, J., Mounien, L., et al. Advances in deoxynivalenol toxicity mechanisms: The brain as a target. Toxins (Basel) 4(11), 1120-1138 (2012).
[4]. Awad, W., Ghareeb, K., B?hm, J., et al. The toxicological impacts of the Fusarium mycotoxin, deoxynivalenol, in poultry flocks with special reference to immunotoxicity. Toxins (Basel) 5(5), 912-925 (2013).