GN44028是一种缺氧诱导因子(HIF)-1的有效抑制剂，其IC50值为14nM。GN44028能抑制低氧诱导的HIF-1α的转录活性，但不抑制HIF-1αmRNA的表达，HIF-1α蛋白的累积或HIF-1α/HIF-1β的异缘二聚化。
CAS：1421448-26-1
分子式：C18H15N3O2
分子量：305.33
纯度：98%
存储：Store at -20°C

Background:

GN44028 is a hypoxia inducible factor (HIF)-1 inhibitor, with an IC50 of 14 nM. GN44028 inhibits hypoxia-induced HIF-1α transcriptional activity without suppressing HIF-1α mRNA expression, HIF-1α protein accumulation, or HIF-1α/HIF-1β heterodimerization[1]. IC50: 14 nM (HIF-1)[1].

[1]. Minegishi H, et al. Discovery of Indenopyrazoles as a New Class of Hypoxia Inducible Factor (HIF)-1 Inhibitors. ACS Med Chem Lett. 2013 Jan 27;4(2):297-301.