4,4'-Dimethoxybenzil是一种人肠胃羧基酯酶(hCECE)抑制剂，Ki为70nM。
CAS：1226-42-2
分子式：C16H14O4
分子量：270.28
纯度：98%
存储：Store at -20°C

Background:

4,4’-Dimethoxybenzil is a human intestinal carboxyl esterase (hiCE) inhibitor with Ki of 70 nM.

By reducing irinotecaninduced diarrhea, hiCE inhibitors (e.g., 4,4’-Dimethoxybenzil, Compound 8) can improve the anti-cancer efficacy of irinotecan. To find effective hiCE inhibitors, a new virtual screening protocol that combines pharmacophore models derived from the hiCE structure and its ligands has been proposed[1].

[1]. GuoDong Zhang, et al. Predicting hiCE inhibitors based upon pharmacophore models derived from the receptor and its ligands. Science China Chemistry