| CAS NO: | 1353224-53-9 |
| 规格: | ≥98% |
| 包装 | 价格(元) |
| 5mg | 电议 |
| 10mg | 电议 |
| 25mg | 电议 |
| 50mg | 电议 |
| Name: CMS121 CAS#: 1353224-53-9 Chemical Formula: C20H19NO3 Exact Mass: 321.1365 Molecular Weight: 321.376 | |
| Storage | -20℃ for 3 years in powder form |
| -80℃ for 2 years in solvent | |
| Technical Information | Synonym: CMS-121, CMS 121, CMS121 Chemical Name: 4-(4-(cyclopentyloxy)quinolin-2-yl)benzene-1,2-diol InChi Key: OMHNVUCFPJJLKD-UHFFFAOYSA-N InChi Code: InChI=1S/C20H19NO3/c22-18-10-9-13(11-19(18)23)17-12-20(24-14-5-1-2-6-14)15-7-3-4-8-16(15)21-17/h3-4,7-12,14,22-23H,1-2,5-6H2 SMILES Code: OC1=CC=C(C2=NC3=CC=CC=C3C(OC4CCCC4)=C2)C=C1O |
| Target | Acetyl-CoA carboxylase 1 (ACC1)[1] |
|---|---|
| In Vitro | CMS-121 (1 μM; 4 hours; HT22 cells) treatment increases the phosphorylation of ACC1 at serine 79. CMS-121 can increase acetyl-CoA in cells[1]. Western Blot Analysis[1] Cell Line: HT22 cells Concentration: 1 μM Incubation Time: 4 hours Result: Increases the phosphorylation of ACC1 at serine 79. |
| In Vivo | CMS-121 (~20 mg/kg; oral administration; daily; for 4 months; female SAMP8 mice) treatment reduces cognitive decline as well as metabolic and transcriptional markers of aging in the brain when administered to rapidly aging SAMP8 mice. CMS-121 preserves mitochondrial homeostasis by regulating acetyl-coenzyme A (acetyl-CoA) metabolism[1]. Animal Model: Female SAMP8 mice (9 months old)[1] Dosage: ~20 mg/kg/day Administration: Oral administration; daily; for 4 months Result: Reduced cognitive decline as well as metabolic and transcriptional markers of aging in the brain. |
| References | [1]. Elevating acetyl-CoA levels reduces aspects of brain aging. Elife. 2019 Nov 19;8. pii: e47866. [2]. Chemical modification of the multitarget neuroprotective compound fisetin. J Med Chem. 2012 Jan 12;55(1):378-89. [3]. Back to the future with phenotypic screening. ACS Chem Neurosci. 2014 Jul 16;5(7):503-13. |
m.cnreagent.com